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Many researchers have concluded that one of the primary causes of aging is the decrease of hgh human growth hormone production. According to Dr. Ronald Klatz, M.D., President of the American Academy of Anti-Aging Medicine, "Aging appears to be due in large part to the drastic decline of growth hormone in the body after adulthood."
According to hgh human growth hormone research, at age 21, the normal level of circulating hgh is about 10 milligrams per deciliter of blood, but at age 61, it's decreased 80% to only 2 milligrams. They say it's growth hormone that grows the cells, bones, muscles, and organs, and it is the level of growth hormone after age 30 that slowly robs us of our youth
After age 30, the secretion rate of hgh drops 14% per decade. By 80, most people barely produce enough hgh to build a fingernail, explaining why injuries experienced by seniors take so long to heal.
The New England Journal of Medicine published the clinical findings of Daniel Rudman, MD, regarding his hgh human growth hormone research on the anti-aging effects of hgh. His findings were astonishing.
Dr. Rudman studied patients age 61 to 81 at the Medical College of Wisconsin-Milwaukee. After six months, Dr. Rudman observed a reversal of the aging process from 10 to 20 years in the patients who received hgh injections. But in the control group (those who didn't receive hgh), the normal aging process continued.
Other hgh human growth hormone research clinical studies performed over the past 30 years have demonstrated that hgh can allow users to lose fat, build muscle mass, improve sexual performance, remove wrinkles, eliminate cellulite, and increase immune function when taken through intra-muscular injections. Hgh is what you might consider a "master hormone" which is secreted by the pituitary gland and is responsible for directly and indirectly balancing the body's critical hormones.
Dr. Chein of the Life Extension Institute in Palm Springs, CA, said he studied 202 patients that he treated with hgh. Here are the results he gave:
Patients reported Improvement in the following areas:
|Attitude Toward Life|
|Body Fat Loss|
|Duration of Penile Erection|
|Frequency of Nighttime Urination|
|Healing of Other Injuries|
|Sexual Function, Sexual Potency/Frequency|
|Menstrual Cycle Regulation|
|Skin & Hair Care, Skin Texture|
|New Hair Growth|
|Energy, Emotions & Memory, Energy Level|
|Resistance to Common Illness|
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According to the president of the American Academy of Anti-Aging Medicine, Dr. Ronald Klatz, "The body-building action of GH has now been shown in many different groups, including athletes, healthy young untrained men, GH-deficient adults, and elderly men." When the GH therapy is stopped, the benefits slowly decline.
Dr. Edmund Chein even makes it a point to not talk about "fat" with his patients because "we talk about percentage of fat and percentage of lean muscle. You are reversing, losing fat and gaining lean muscle. Your net weight may stay the same or even go up."
In a recent BBC article, they identify HGH as being potentially the next "Sports Menace".
Why? In their article titled "Human growth hormone explained," the BBC points out the potential muscle building and performance enhancing capabilities of GH. Their concern lies in the fact ".. it is almost impossible to set a blood level of GH that would be considered unnaturally high and indicative of doping, because levels of naturally-occurring GH can vary by more than 100-fold in response to factors such as nutritional state, sleep and exercise."
Regardless of perspective, the one thing all three of these sources agree on is clear. They all agree upon the benefits of GH for muscle building as well as athletic performance.
As medicine enters the 21st century, there is growing recognition from physicians, clinicians and biomedical researchers that human lifespan can be prolonged and that premature deterioration from things such as cardiovascular disease, cancer, diabetes, stroke and neurodegenerative disorders such as Alzheimer's and Parkinson's may be delayed and prevented. At the center of much of this research is H.G.H. or Human Growth Hormone.
The following is a direct quote from the American Academy of Anti-Aging Medicine web-site.
While most people think of GH as the miraculous treatment for children doomed to dwarfism (over the past 30 years it has saved tens of thousands from this fate). HGH therapy has been so effective for our young that a remake of The Wizard of Oz is nearly impossible today, due to this medical achievement.
The next great benefit of HGH therapy appears to be in the aging population.
People with age related deficiency of GH become fat, flabby, frail, and lethargic, lose interest in sex, have trouble sleeping, concentrating, remembering things, tire easily, and in general, lose their zest for life.
With HGH, all these so-called signs of aging are reversed.
When Dr. Daniel Rudman, a pioneer researcher and his colleagues at the Medical College of Wisconsin published their article in teh prestigious New England Journal of Medicine they broke new ground in the field of anti-aging medicine.
It was the first clinical trial of elderly men on GH, comparing the effects of six months' of GH injections on twelve men, ages sixty-one to eighty-one, with an age-matched control group. Their results made headlines all over the world. Those taking the hormone injections gained an average of 8.8 percent in lean body mass and lost 14 percent in fat, without diets or exercise. Their skin became thicker and firmer and the lumbar bones of the spine increased.
Published in the New England Journal of Medicine, the researchers wrote: "The effects of six months of human growth hormone on lean body mass and adipose-tissue mass were equivalent in magnitude to the changes incurred during 10 to 20 years of aging."
It's important to realize, HGH declines with age in every animal species that has been evaluated to date.
In humans, the amount of GH after ages twenty-one to thirty-one falls about 14 percent per decade, so that the total twenty-four-hour GH production rate is reduced in half by age sixty. In numerical values, on a daily basis we produce about 500 mcg (micrograms) at age twenty, 200 mcg at age forty, and 25 mcg at age eighty. The fall in IGF-1 with an increase in age mirrors that of HGH.
Each bottle contains 15 IU (5mg) of biosynthetic human growth hormone (from recombinant DNI), excipients include Glycine, mannitol, bibasic sodium phosphate. Each bottle of diluent contains m-cresol, glycerin and water for injections.
Pharmaceutical Classification of Humatrope:
Sterile freeze-dried powder of systemic hormone preparation.
Directions for usage of Humatrope:
Long-term treatment for stunted growth, due to the reduction or lack of somatotrophic endogenous hormone secretion in-patients who have not yet finished puberty. Treatment of short stature in girls suffering from Turner's syndrome confirmed by chromosomal analysis (the effect on final height has not yet been established).
Contraindications using Humatrope:
Hypersensitivity in certain patients to the product or any of its ingredients. Patients with complete knitting of the epiphyses. Diabetes mellitus. Humatrope should not be used if there is any sign of active neoplasms. Endocrane lesions must be inactive and anti-tumoral treatment finished before beginning hormonal treatment. The use of Humatrope must be interrupted in the event of renewed tumoral growth. Humatrope must not be reconstituted with the accompanying diluent if the patient is sensitive to m-cresol or glycerin.
Precautionary measures in the usage of Humatrope:
Humatrope treatment should only be carried out under a doctor's authorization, by prescription, by university medical centers or hospitals specializing in the treatment of patients with growth hormone deficiency. Diagnoses must be confirmed before beginning Humatrope injections. This requires a clinical examination of the patient with detailed case histories, particularly with regard to auxilogical evaluations and the carrying out of laboratory tests, including stimulus test, to verify hypophysial hypothalamus functioning. Humatrope therapy should be carried out by a specialist in the diagnosis and treatment of patients related to stunted growth. Patients who, following diagnosis, undergo treatment with the somatotrophic hormone will have to be inscribed in a regional register and monitored by means of clinical auxilogical and laboratory evaluations every six months to check the functioning of the thyroid, glucide metabolism etc. The lack of available information may mean the exposure of the patient to a risk, which may exceed the therapeutic benefit obtained. Human hormone growth treatment should be complemented by an adequate supply of calories and amino acids. Once reconstituted with the accompanying diluent, Humatrope can be taken in subcutaneous or intramuscular injections.
Carcinogenesis, Mutagenesis and Fertility Alterations using Humatrope:
Long term studies with Humatrope on animals have not been carried out, which would enable the evaluation of any carcinogenic or fertility altering effect which this pharmaceutical product may possibly have. No mutagenic effect due to Humatrope has been seen in tests up to the present.
Using Humatrope during pregnancy and nursing:
Studies on Humatrope and its effects on animal reproduction have not been carried out. It has not been seen that Humatrope can harm the fetus during pregnancy, nor that it can affect reproduction. Nevertheless, Humatrope should only be taken during pregnancy if absolutely necessary. Studies of the effects of Humatrope on nursing mothers have not been carried out and hence it is not known whether this product is excreted into mother's milk. However, since many pharmaceutical products are indeed passed into mother's milk, nursing mothers are advised to take Humatrope with extreme caution.
Interactions using Humatrope:
Since taking Humatrope may cause resistance to insulin, patients should undergo periodic check ups in order to detect any intolerance to glucose. Children suffering from diabetes mellitus should be carefully supervised during Humatrope treatment, as it may be necessary to increase their insulin dosage. Excessive glucocortoid treatments may inhibit the effect of growth stimulation provided by the human somatotrophic hormone. In the case of patients who also suffer from ACTH (adrenocrticotrophic hormone) deficiency, the substitutive dosage of glucocorticoids must be accurately regulated in order to prevent any inhibitory effect on growth.
Please be advised when using Humatrope:
Attentive and constant supervision by the specialist is advised during growth hormone treatment of patients with neoplasms in remission. Those with a shortage of the growth hormone accompanying an endocrane lesion must be checked particularly frequently so as to prevent spreading or a relapse. Patients with growth hormone deficiency may frequently show alterations having to do with the epiphysis. For this reason, children who limp or show unsteadiness in their walking during growth hormone treatment should have thorough check ups. Hypothyroidism may arise during Humatrope treatment. Because untreated hypothyroidism can prevent an optimal response to Humatrope, patients should have periodic tests for thyroid functioning and undergo thyroid hormone treatment when necessary. Patients with psoriasis are also advised to have regular check ups so as to avoid a possible aggravation of the condition. In the event of sensitivity to the accompanying diluent, the bottles may be reconstituted with sterile water for injections. If Humatrope is reconstituted this way, the solution must be administered within 24 hours and any left over solution thrown away. If, once reconstituted, the solution is not administered immediately, it may be kept up to 24 hours in the refrigerator at a temperature between +2 degrees Celsius and +8 degrees Celsius. Humatrope's effect on the patient's capacity to drive or operate machinery has not been determined.
Directions for usage of Humatrope:
Dosage and duration of treatment are to be decided by the specialist according to the needs of the patient.
Patients using Humatrope for growth hormone deficiency:
The recommended subcutaneous or intramuscular dosage is 0.18 mg/ kg of body weight (0.48 IU/ Kg) per week, approximately equivalent to 12 IU/m2 per week. The weekly dosage is to be divided into either 3 intramuscular injections or 6 to 7 subcutaneous injections.
Patients with Turner's syndrome administering Humatrope:
The recommended dosage is 0.3- 0.34 mg/ Kg of body weight (0.8- 0.9 IU/ Kg) per week, equivalent to 24- 28 IU m2 per week. The weekly dosage is to be divided into 6-7 subcutaneous injections, to be administered preferably in the evening. With subcutaneous injection, it is advised that the place of injection be varied so as to avoid the onset of lipoatrophy. To prepare the Humatrope solution: Inject 0.5- 2ml of the diluent into the bottle containing the freeze-dried powder, directing the flow of the liquid towards the sides of the bottle. Then shake the bottle with a gentle rotating movement until the contents are completely dissolved. DO NOT SHAKE VIGOROUSLY . The use of sterile syringes and needles are recommended for the injections. After reconstitution, the solution must be transparent and without precipitates. If it is opalescent or has precipitates, then it MUST NOT be used. Clean the surface of the bottle's rubber stopper with antiseptic before and after using it to prevent contaminating its contents. Syringes must have a volume small enough to enable the prescribed dosage to be extracted with reasonable accuracy
Directions for reconstitution and administration of Humatrope:
Do not reconstitution or administer this pharmaceutical product without first receiving adequate instructions as to the correct technique by the specialist. Follow the doctor's sterilizing technique by the specialist. Follow the doctor's sterilizing technique. Destroy and get rid of syringes or needles following each use. Humatrope must be kept in a cool place (from +2 degrees Celsius to +8 degrees Celsius) after reconstitution (refrigerator). DO NOT FREEZE. ONCE RECONSTITUTED, HUMATROPE MUST BE USED WITHIN 21 DAYS.
Reconstitution of the Humatrope bottle:
Reconstitute Humatrope only with Humatrope diluent. Do not use any other solution for reconstitution unless it is by your doctor's prescription. The doctor will also decide the correct sizes of the syringe and needle and the amount of diluent to add to the Humatrope bottle. ALWAYS WASH YOUR HANDS FIRST.
Remove and throw away the stoppers of the bottles of diluent and of Humatrope. Clean the rubber covering of the bottles with cotton wad soaked in alcohol (see figure 1 in pack). Remove the protective covering of the needle and set it aside. Pull the piston of the syringe until the same volume of air is let in as the volume of diluent prescribed by the doctor. Insert the needle into the rubber stopper of the bottle of diluent and inject air into the bottle.
Holding the bottle upside down and making sure that the needlepoint is in the solution, extract the amount of diluent prescribed by the specialist (see figure 2 in pack). Once you are sure there are no air bubbles left in the syringe, turn the bottle right side up and extract the syringe, taking care that the position of the piston does not change.
Insert the same needle into the bottle of Humatrope and gently turn the needle point inwards towards the side of the bottle. Slowly inject the diluent, directing the flow towards the side (see figure 3 in pack). DO NOT AIM IT IN THE DIRECTION OF THE WHITE POWDER AT THE BOTTOM OF THE BOTTLE. To balance the pressure and before removing the syringe from the bottle, let in a volume of air equal to that of the diluent just added. If the needle can become separated from the body of the syringe, remove, destroy and throw it away. If the needle and the syringe cannot be separated, eliminate the entire unit.
Shake the bottle with a gentle rotating movement until the contents are completely dissolved (see figure 4 in pack)
Preparing the Humatrope injections:
-Do not use Humatrope, if upon reconstitution, it is opalescent or contains precipitates.
-If the needle can be separated from the syringe, apply a new needle before giving the injection. If the syringe and needle from an inseparable unit use another syringe for the preparation of the injection.
-Before and after administrating the injection, the rubber stopper of the bottle must be cleaned with alcohol or an alcohol based antiseptic solution to avoid that repeated insertions of the needle contaminate the contents.
-Remove the cover of the needle and let an amount of air equal to the amount of Humatrope into the syringe.
-Insert the cover of the bottle of reconstituted Humatrope and inject air into the bottle. Turn the bottle upside down and making sure that the needlepoint is in the solution, inject the exact dosage (see figure 2 in pack). Make sure that there are no air bubbles in the syringe.
-Remove the syringe and wrap up the needle. Write down the date of reconstitution on the label of the bottle and eliminate any diluent, which has not been used.
-Put the unused part of reconstituted Humatrope in the refrigerator and use it within 21 days.
-Destroy the needle or syringe needle unit once finished.
-Tap the spot chosen for the injection gently with one finger.
-Carefully clean the area with a cotton wad, which has been soaked in alcohol, making a circular movement, moving from the inside of the circle outward.
Stabilize the skin between the thumb and the index finger and raise an ample portion of skin. Holding the needle at a 90-degree angle to the spot chosen for the injection, insert the entire needle into the skin. Slowly inject the liquid. Remove the needle quickly, exerting pressure on the place chosen for the injection with a dry gauze pad or a cotton wad. Rub for several seconds. Destroy the needle or the needle, syringe unit.
With the thumb and first two fingers, press firmly against an ample portion of muscle mass, such as the thigh. Holding the syringe at a 90-degree angle to the spot chosen for the injection, insert the entire needle into the skin. Holding the needle inside the place chosen for injection, slowly pull back the piston. Should blood appear in the syringe, remove the needle, throw out the syringe with the pharmaceutical product and prepare another injection. If blood does not enter the syringe, slowly inject the solution. Pull the needle out quickly, exerting pressure on the place of injection with a dry gauze pad or cotton wad. Rub for several seconds. Destroy the needle or the needle/ syringe unit when finished. If you are in any doubt, consult your doctor.
In case of overdose using Humatrope:
Overdose may cause hypoglycemia followed by hyperglycemia. Long term overdose may result in symptoms of acromegaly, similar to the effects of an excess of human somatotrophic hormone.
Humatrope Side Effects:
In the course of clinical research studies on patients with growth hormone deficiency, which has never been treated on patients with Turner's syndrome, a development of antibodies against the growth hormone, has been detected, but which has no effect on the rhythm of growth. Up to the present, long term effects caused by the presence of these antibodies have not been noted. Research into antibodies against the growth hormone should be carried out on all subjects who fail to respond to treatment. High doses of Humatrope deliberately given to healthy adults have on rare occasions produced the following effects- headache, local muscular pain, weakness, mild hypoglycemia and glycosuria. In studies on children with growth hormone deficiency, rare cases have been reported of pain in the area of the injection. 2.5% of those children treated has shown mild transitory oedema in the early stages of treatment. Should the patient notice any unpleasant side effect not described in this leaflet, he should consult his specialist or family doctor. Attention- Do not use this or any medicine once its expiry date has passed.
Special notes on storage of Humatrope:
Store in the refrigerator at +2 degrees Celsius to +8 degrees Celsius after reconstitution. Keep the diluent and the reconstituted product from freezing. If reconstituted with the accompanying diluent, the product may be kept for 21 days in the refrigerator without significant loss of properties.