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Growth hormone deficiency causes are different in children and adults, sometimes no cause can be identified. Whenever in medicine, we found no identifiable cause, we use the term idiopathic. Causes of growth hormone deficiency are different in children and adults. Some of the causes are reversible and some causes are irreversible such as injury or trauma to our beautiful pituitary gland.
A Lot of research has been done to find out the causes of growth hormone deficiency. It is rarely passed from parents to offsprings, so genetics is a rare cause. But children who are borne with other congenital problems such as cleft lip and cleft palate can develop growth hormone deficiency.
The pituitary gland which is located at the base of the brain and normally produces growth hormone is unable to perform its function in growth hormone deficiency. If this problem is present at birth, this is called congenital growth hormone deficiency. If this develops in adulthood, we call it acquired growth hormone deficiency.
Congenital growth hormone deficiency
In congenital growth hormone deficiency, the development of the pituitary gland is delayed or affected. These are pituitary aplasia, pituitary hypoplasia, anencephaly, midfacial anomalies.
Pituitary aplasia refers to the condition when the pituitary gland is absent (not developed at all). Sometimes, a rudimentary gland is present in normally developed sella turcica. Sella turcica is part of the base of the skull which normally contains the pituitary gland. Pituitary hypoplasia is an underdeveloped pituitary gland that produces low levels of growth hormone. In Anencephaly, a large part of the skull is absent along with hemispheres of the cerebrum.
Acquired causes of growth hormone deficiency
1. Severe head injury: Head injury can damage pituitary gland. Part of ghe pituitary gland that produces HGH or somatotropin is more vulnerable to damaging effects of head injury.
2. Tumor in the brain or pituitary gland: A tumor in the brain surrounding the pituitary gland can compress normally developed pituitary gland. Normal blood supply of the pituitary gland is occluded by pressure effects and it can develop necrosis. The same occurs in the tumor of the pituitary gland itself.
3. Infection of the pituitary gland: These infections present with headaches and problems of vision. A large number of patients develop hypothalamic-pituitary dysfunction. Other associations in the acute phase of infection are raised body temperature and leukocytosis (increased which blood cells count).
4. Brain surgery: Either surgery is for tumors of other parts of the brain or pituitary gland itself, there is a significant risk of damaging the normal portion of the pituitary gland. Sometimes, when there is pituitary adenoma and neurosurgeon performs surgery to remove this tumor, he can damage the normal part of the gland.
5. Poor blood supply to the pituitary gland: The pituitary gland can be divided into the anterior pituitary gland and the posterior pituitary gland. Human growth hormone is produced normally from the anterior pituitary gland. `it is supplied by superior hypophyseal artery which is a branch of internal carotid artery.
When these vessels are narrowed due to aging and atherosclerosis or occluded by an embolus, integrity of this beautiful gland is affected and enough HGH cannot be produced.
If you are searching for injectable growth hormone products, which can boost your energy level, sexual performance, slow down your aging process or if you are worried about the short stature of your child, definitely you are at the right place.
In this article, we have briefly explained about Xerendip which is synthetic Human growth hormone also known as somatropin. Somatropin is available in different brand forms such as Genotropin, norditropin, xerendip but this article is specifically focused on Xerendip injection which is manufactured by PISA laboratories.
It has different indications for pediatrics and adult patients.
Indications in children:
• Growth failure due to underproduction of natural growth hormone.
• Short stature due to Noonan or Turner syndrome.
• Prader-Willi syndrome causing growth failure.
• Idiopathic short stature.
Indications in adults:
Whenever there is a deficiency of growth hormone in adults, norditropin is used as replacement therapy.
Important information to know before using Xerendip (Somatropin):
Before you start using somatropin:
Tell your physician about your past and present medical history, especially allergies, surgery, diabetes, cancer, respiratory problems, liver and kidney disease, scoliosis, high blood pressure, underactive thyroid, and a brain tumor.
Also tell your doctor about all other drugs you use, especially, if you are taking steroids or diabetes medications such as insulin or other oral hypoglycaemic agents. Weekly or monthly dosages of these medicines may need to be changed when you start using xerendip which is synthetic Human Growth Hormone. It is very important to mention here that do not change the dose of steroid suddenly or change any of your medication doses without your doctor's advice.
If you are suffering fron Prader-Willi syndrome and are using xerendip (HGH), call your doctor immediately f you develop signs of breathing problems such as dyspnoea which is actually shortness of breath, new or increased snoring, and cough. If you have sudden and severe pain in your epigastrium (the area of your tummy above umbilicus and below sternum) with nausea and vomiting, fast heartbeat, increased thirst or urination, or vision changes and sudden, severe pain behind your eyes, call your doctor promptly.
Tell your doctor at once if you have any of these serious side effects:
- Increased desire for water or feeling thirsty.
- Increased frequency of urination, increased appetite, dryness of mucous membranes of your mouth.
- Fruity or sweet breath odor which means you may be developing diabetic ketoacidosis if you are already diabetic.
- Dry skin, and weight loss.
- Pain behind your eyeballs which is unbearable and sometimes associated with visual changes.
- Swelling of your face, hands and feet.
- Tingling sensations in your body especially wrist, fingers, and sometimes in whole hand.
- Severe pain in your epigastrium, which is the are in your abdomen containing your stomach.
Less serious side effects may include:
- Feeling of tiredness of headache which is sometimes not relieved by pain killers.
- Local allergic reaction to xerendip which can manifest as redness, swelling, itching, rash, pain, where the medicine was injected. Sometimes, bruising also occurs at the site of injection.
- Pain in your arms or legs.
- Stiffness of joints.
- Symptoms of flu or cold such as sneezing and blockage of your nose.
Active ingredient of Genotropin is somatropin, produced through recombinant DNA technology.
The amino acid sequence of this synthetic product is identical to that of HGH of pituitary gland origin, therefore stimulating linear growth in children; tissue growth; carbohydrate, lipid, protein, mineral and bone marker metabolism. It increases serum insulin-like growth factor-1.
Genotropin has been approved for the following indications:
1. Treatment of short stature associated with Turner syndrome in patients when growth plates are still present.
2. The treatment of children who have growth failure due to growth hormone deficiency in which endogenous hormone is not produced or produced in low quantity.
3. It can also be used as replacement of endogenous growth hormone in adults with adult or childhood-onset growth hormone deficiency.
4. Treatment of growth failure in children who are born small for gestational age.
5. Long-term treatment of ISS (idiopathic short stature)
The recommended dose of Genotropin for Growth hormone deficiency in children is 0.16 mg/kg to 0.24 mg/kg body weight per week.
It is divided into 6 to 7 doses and injected subcutaneously. The dose of Genotropin should be adjusted accordin to the concentration of Insulin like growtg factor 1 and adverse effects.
It is available market in numerous formulations (0.6 mg, 0.8 mg, 1.0 mg, 1.4 mg, 1.6 mg, 1.8 mg, and 2.0 mg syringes, and 5.3 mg and 12 mg pens), which are for subcutaneous injection using one of the following devices:
2. GoQuick pen
Standard of therapy in Growth Hormone Deficiency
Once the diagnosis of Growth hormone deficiency is established in children, Genotropin (also called somatropin) therapy is recommended as soon as possible in order to enhance growth velocity and if the therapy is not started in childhood, normal final height is difficult to achieve.
Results of previous researches indicated that somatropin is effective in children with growth hormone deficiency. If started in early childhood, normal final height can be achieved. Somatropin products such as Genotropin, Norditropin, Saizen, Humatrope, Xerendip and Zomacton are considered safe for both short-term and long-term treatment.
There may be a question arising in your mind that these different products of somatropin may have different clinical effectiveness and different safety profile but there are suggestions that the clinical effectiveness and safety profile of these products (Norditropin, saizen, Genotropin) are similar.
We deal in different products of somatropin (recombinant human growth hormone), providing these products at rates that are lowest in market.
You can also read other articles about growth hormone, such as:
How does it function in body?
What are chemical properties of growth hormone?
What are the causes of growth hormone deficiency?
Should I use recombinant human growth hormone to make myself more energetic?
We strongly suggest you should read more about somatropin and make a purchase from us.
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